Calcification of glutaraldehyde-fixed porcine xenograft.
نویسندگان
چکیده
The clinical and light and electron microscopic findings are reported in a 14-year-old patient who died 12 months after mitral valve replacement with a Hancock prosthesis. Severe cusp calcification had led to immobilisation of the valve and stenosis. Calcification involved the substance of the valve cusps. The cause of the calcification in this patient is unknown.
منابع مشابه
Xenograft Failure of Pulmonary Valved Conduit Cross-linked with Glutaraldehyde or Not Cross-linked in a Pig to Goat Implantation Model
BACKGROUND Biologic valved grafts are important in cardiac surgery, and although several types of graft are currently available, most commercial xenografts tend to cause early disfiguration due to intimal proliferation and calcification. We studied the graft failure patterns on non-fixed and glutaraldehyde-fixed pulmonary xenograft in vivo animal experiment. MATERIALS AND METHODS Pulmonary va...
متن کاملRe: development of a next-generation tissue valve using a glutaraldehyde-fixed porcine aortic valve treated with decellularization, α-galactosidase, space filler, organic solvent and detoxification.
Bioprosthetic heart valves are made with porcine aortic valves or constructed with bovine pericardium, both cross-linked with glutaraldehyde (GA). The main problem with bioprosthetic valves is tissue degeneration owing to tissue fatigue and calcification [1]. The GA fixation is commonly used to provide resistance to biodegradability and to reduce the antigenic host response. Unfortunately, the ...
متن کاملDetoxification of Glutaraldehyde Treated Porcine Pericardium Using L-arginine & NABH4
BACKGROUND Calcification is the most frequent cause of clinical failure of bioprosthetic tissues fabricated from GA-fixed porcine valves or bovine pericardium. A multi-factorial approach using different mechanisms was recently developed to reduce the calcification of bioprosthetic tissues. The purpose of the present study was to evaluate the synchronized synergism of using L-arginine and NaBH(4...
متن کاملStudy on Genipin: A New Alternative Natural Crosslinking Agent for Fixing Heterograft Tissue
BACKGROUND In cardiac surgery, especially in the reconstruction of vascular structures and intracardiac defects, glutaraldehyde has usually been used as the reagent for fixing porcine or bovine pericardial tissues. But the well-known problem of calcification or cytotoxicity of glutaraldehyde motivates the search for a replacement. The aim of this study is to investigate the physical, mechanical...
متن کاملDevelopment of a next-generation tissue valve using a glutaraldehyde-fixed porcine aortic valve treated with decellularization, α-galactosidase, space filler, organic solvent and detoxification.
OBJECTIVES Conventional crosslinking with glutaraldehyde (GA) renders cardiac xenografts inert, non-biodegradable and non-antigenic, but is a main cause for dystrophic calcification due to phospholipids, free aldehyde groups and residual antigenicity. A significant immune reaction to the galactose-α-1,3 galactose β-1,4-N-acetylglucosamine (α-Gal) of a GA-fixed cardiac xenograft occurs, leading ...
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ورودعنوان ژورنال:
- Thorax
دوره 33 1 شماره
صفحات -
تاریخ انتشار 1978